Endocrine Abstracts

Introduction: Obesity is a major risk factor for the development of hyperlipidemia and its related cardiovascular complications. Apart from its well-established role in cancer biology, the MDM2-p53 axis has been recently shown to regulate glucose and lipid metabolism. Our preliminary data indicated that MDM2 is dramatically induced in the liver of obese mice. In this study, we aimed to investigate the potential role of hepatic MDM2 in controlling systemic lipid homeostasis usi...